Temperature Sensor

Project Graphic Express Summary This research aims to develop a molecular probe that can be used to measure temperature in vivo during magnetic resonance imaging (MRI). We used virtual screening to identify organofluorine compounds that could potentially improve the accuracy and sensitivity of 19F MRI-based temperature monitoring. In collaboration with our experimental team, we have developed a perfluoro-sulfane-based compound that showed a nearly 2-fold increase in temperature responsiveness compared to the current standard 19F MRI temperature sensor (perfluoro-tributylamine) and the 1H resonance frequency, a standard parameter used for temperature mapping in MRI.