Mechanistic Insights into Radical Formation and Functionalization in Copper/N-Fluorobenzene­sulfonimide Radical-Relay Reactions

TOC Graphic Published In Chemical Science Authors Mukunda Mandal,‡* Joshua A. Buss,‡ Si-Jie Chen, Christopher J. Cramer and Shannon S Stahl* (‡Contributed Equally; *Corresponding Author) Citation Mandal, M.; Buss, J. A.; Chen, S.-J.; Cramer, C. J.; Stahl, S. S. Mechanistic Insights into Radical Formation and Functionalization in Copper/N-Fluorobenzene­sulfonimide Radical-Relay Reactions. Chem. Sci. 2024, 15, 1364. Express Summary In Cu-catalyzed C(sp3)–H functionalization with NFSI, the Cu-bound •NSI radical is the active HAT reagent and selectively activates benzylic C–H bonds over 3° C–H bonds (superior vs.